外泌体（exosomes）是一种能被机体内大多数细胞分泌的直径大约为 30 ~ 150 nm 的具有脂质双分子层膜结构的微小囊泡。大多数类型的细胞都可以分泌外泌体，同时外泌体也广泛存在于体液中，包括血液、眼泪、尿液、唾液、乳汁、腹水等。目前研究发现外泌体中富含核酸（mRNA、microRNA、lncRNA、circRNA 等）、蛋白、脂质等活性生物分子。外泌体频繁穿梭于细胞之间，为细胞之间的通信提供了桥梁。因此，外泌体几乎可以与任何疾病相关联，成为疾病标志物、疾病机理、药物开发等研究的创新热点。
| 华盈生物外泌体服务体系
外泌体的研究是一项系统工程，从生物样本的保存开始，到外泌体的提取、鉴定与质检、内容物组学分析、验证、功能实验等，均需较高技术水准作为保障才能够确保实验结果的优质可靠。华盈生物自2017 年始，全力打造外泌体“一站式”研究服务平台，逐步建立了包含外泌体的提取及鉴定、外泌体标记/ 示踪、外泌体蛋白质组学/转录组学分析等全方位技术体系，以“高品质服务”为宗旨，力求为广大科研用户提供在外泌体研究方面全方位的支持和便利。
| 华盈生物外泌体服务优势
华盈生物根据不同的样品类型和研究目的，推出优选的外泌体分离方法，并提供全套的外泌体研究技术服务。在分离高质量外泌体的基础上，进行外泌体中的蛋白质和核酸组分的高通量筛选和分析。华盈生物开发的组学研究技术服务体系进行了系统性创新优化，将样本用量降低的同时获取高质量数据。华盈生物利用1mL血浆即可进行外泌体的分离和测序，并能稳定获得超过1万条长链RNA。同时，华盈生物利用0.5mL血浆即可完成外泌体的分离与蛋白质组筛选工作，并不断冲击外泌体蛋白质组学检测的上限，例如：在人外泌体血浆蛋白组鉴定历史记录已达到2336种蛋白质，并且这个数据记录每天都可能被再次突破。
| 华盈生物外泌体项目经验
截止目前，华盈生物已经完成超过30种样品类型的样品外泌体制备与分析。对于特殊样本如：胃液、脑积液、脑脊液、胆汁、微生物培养液、植物培养液等，也累积了丰富的项目经验，可承接复杂样品和项目的研究服务需求。
| 客户文献
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[8]. Tian Wang, Zhe Jian, Andrius Baskys, et al. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020 Oct;257:120264. IF=12.479
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