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| 销售商： 上海神思药得科技有限公司 | 查看该公司所有产品 >> |
神思药得科技提供优化过的稳定表达离子通道细胞系，通道序列清晰，完成全套的表达验证、功能测试、微生物检测和健康认证，提供完整的细胞授权文件以满足GLP实验和申报的需求。
细胞系包括Nav1.8, hERG, Nav1.5, Cav1.2, GABAa等。优化后的细胞株质量可靠，电流清晰，可保证膜片钳分析能获得稳定的实验数据。可应用在癫痫、镇痛等多个领域离子通道靶点药物高通量筛选和早期药物研发，亦可满足临床前心脏安全性评价CiPA需求。
- 全套验证文件与授权
- 经过专门优化挑选
- 易形成紧密高阻抗封接
- 优化的成功率
- 稳定的电流反应
- 优化的实验溶液配方和标准化细胞培养方案
- 实验技术支持
- 用户定制与分析
- 基于稳转细胞株的药物筛选和检测服务
更多其他离子通道稳转细胞系和检测服务，欢迎留言详询。
现有离子通道细胞系（进口）列表：
电压门控类
Potassium channels
| Target | Gene | Disorder | Cell Type | |
| KV1.1 | KCNA1 | Seizure disorders | CHO | |
| KV1.2 | KCNA2 | Seizure disorders | CHO | |
| KV1.3 | KCNA3 | Immune system related | CHO | |
| KV1.4 | KCNA4 | - | CHO | |
| KV1.5 | KCNA5 | Heart function | CHO | |
| KV1.6 | KCNA6 | - | CHO | |
| KV1.7 | KCNA7 | - | CHO | |
| KV2.1 | KCNB1 | - | CHO | |
| KV2.1 | KCNB1 | HEK 293 | ||
| KV2.2 | KCNB2 | - | CHO | |
| KV2.2 | KCNB2 | - | HEK 293 | |
| KV3.1a (short) | KCNC1 | - | CHO | |
| KV3.1b (long) | KCNC1 | - | CHO | |
| KV3.2 | KCNC2 | - | CHO | |
| KV3.3 | KCNC3 | - | CHO | |
| KV3.4 | KCNC4 | - | CHO | |
| KV4.2 | KCND2 | - | CHO | |
| KV4.3 | KCND3 | - | CHO | |
| KV4.3 | KCND3 | - | HEK 293 | |
| KV4.3 KChip | KCND3 | - | CHO | |
| KV7.1 (KVLQT1) | KCNQ1 | - | HEK 293 | |
| KV7.1 (KVLQT1) | KCNQ1 | LQT Syndrome 1/5 | HEK 293 | |
| KV7.1 (KVLQT1) | KCNQ1 | LQT Syndrome 1/5 | CHO | |
| KVLQT1/minK | KCNQ1/KCNE1 | LQT Syndrome 1/5 | HEK 293 | |
| KVLQT1/minK | KCNQ1/KCNE1 | LQT Syndrome 1/5 | CHO | |
| KV7.2 | KCNQ2 | Epilepsy | CHO | |
| KV7.3 | KCNQ3 | Epilepsy | CHO | |
| KV7.2/3 | KCNQ2/3 | Epilepsy | CHO | |
| KV7.2/3 (rat) | KCNQ2/3 | Epilepsy | CHO | |
| KV7.3/5 | KCNQ3/5 | - | CHO | |
| KV10.1 | KCNH1 | - | CHO | |
| K2P18.1 | KCNK18 | - | HEK 293 | |
| SK4 KCa3.1 | KCNN4 | - | CHO | |
| hERG | KCNH2 | LQT Syndrome 2 | HEK 293 | |
| hERG | KCNH2 | LQT Syndrome 2 | HEK 293 | |
| hERG | KCNH2 | LQT Syndrome 2 | CHO | |
| hERG | KCNH2 | LQT Syndrome 2 | CHO | |
| hERG Duo | KCNH2 | LQT Syndrome 2 | CHO | |
| Kir1.1 | KCNJ1 | - | CHO | |
| Kir2.1 | KCNJ2 | LQT Syndrome | CHO | |
| Kir2.2 | KCNJ12 | - | CHO | |
| Kir2.3 | KCNJ4 | - | HEK 293 | |
| Kir2.3 | KCNJ4 | - | CHO | |
| BK α1 | KCNMA1 | - | CHO | |
| BK α1 | KCNMA1 | - | CHO | |
| BK α1β2 | KCNMA1 / KCNMB2 | - | CHO | |
| BK α1β4 | KCNMA1 / KCNMB4 | - | CHO | |
| KCa2.2 (SK2) | KCNN1 | - | CHO | |
|
KCa2.1 / KCa2.2 (SK1/SK2)
|
KCNN2 / KCNN1 | - | CHO | |
| HCN Channels | ||||
| Target | Gene | Disorder | Cell Type | |
| HCN1 | HCN1 | - | HEK 293 | |
| HCN2 | HCN2 | - | HEK 293 | |
| HCN2 (rat) | HCN2 | - | HEK 293 | |
| HCN4 | HCN4 | - | HEK 293 | |
| HCN4 (rat) | HCN4 | - | HEK 293 | |
| Sodium Channels | ||||
| Target | Gene | Disorder | Cell Type | |
| NaV1.1 | SCN1A | - | CHO | |
| NaV1.2 | SCN2A | - | CHO | |
| NaV1.3 | SCN3A | Epilepsy / Pain | CHO | |
| NaV1.4 | SCN4A | - | HEK 293 | |
| NaV1.4 | SCN4A | - | CHO | |
| NaV1.5 | SCN5A | LQT Syndrome 3 | HEK | |
| NaV1.5 | SCN5A | LQT Syndrome 3 | HEK | |
| NaV1.5 duo | SCN5A | LQT Syndrome 3 | CHO | |
| NaV1.5 big late | SCN5A L409C/A410W | LQT Syndrome 3 | HEK 293 | |
| NaV1.5 ΔKPQ | SCN5A ΔKPQ | LQT Syndrome 3 | HEK | |
| NaV1.6 | SCN8A | - | CHO | |
| NaV1.7 | SCN9A | - | CHO | |
| NaV1.7 | SCN9A | - | CHO | |
| NaV1.8 | SCN10A/SCN3B | - | CHO | |
| NaV1.9 | SCN11A | - | HEK | |
|
Calcium Channels |
||||
|
Target
|
Gene | Disorder | Cell Type | |
| CaV1.2 | CACNA1C/CACNB2/ CACNA2D | - | HEK 293 | |
| CaV3.1 | CACNA1G | - | CHO | |
| CaV3.2 | CACNA1H | - | HEK 293 | |
| CaV3.3 | CACNA1I | - | HEK 293 | |
| CaV3.3 | CACNA1I | - | CHO | |
|
Chloride Channels |
||||
| Target | Gene | Disorder | Cell Type | |
| CFTR | CFTR | - | CHO | |
| CFTR | CFTR | - | HEK 293 | |
| ClC-1 | CLCN1 | - | HEK 293 | |
| ClC-1 | CLCN1 | - | CHO | |
|
TRP Channels |
||||
| Target | Gene | Disorder | Cell Type | |
| TRPA1 | TRPA1 | - | HEK 293 | |
| TRPA1 | TRPA1 | - | CHO | |
| TRPV1 | TRPV1 (VR1) | - | CHO | |
| TRPV1 (mouse) | TRPV1 (VR1) | - | CHO | |
| TRPV3 | TRPV3 | Olmsted syndrom | CHO | |
| TRPV3 (mouse) | TRPV3 | Olmsted syndrom | CHO | |
| TRPV4 | TRPV4 | Dwarfism, Neuropathy | HEK 293 | |
| TRPV4 (mouse) | TRPV4 | Dwarfism, Neuropathy | CHO | |
| TRPM4 | TRPM4 | - | CHO | |
| TRPM8 | TRPM8 | Pain sensation | HEK 293 | |
| 配体门控类 | ||||
| GABAA Receptors | ||||
| Target | Gene | Disorder | Cell Type | |
| GABA α1β2γ2 | GABRA1 / GABRB2 / GABRG2 | - | CHO | |
| GABA α2β2γ2 | GABRA2 / GABRB2 / GABRG2 | - | HEK | |
|
Glutamate Receptors |
||||
| Target | Gene | Disorder | Cell Type | |
| Kainate K2 | GRIK2 | - | CHO | |
| Kainate K2 | GRIK2 | - | HEK 293 | |
| NMDAR1 | GRIN1 | Mental retardation | CHO | |
| NMDA 1/2A | GRIN1/GRIN2A | Epilepsy | HEK 293 | |
| NMDA 1/2B | GRIN1/GRIN2B | Depression | HEK 293 | |
| NMDA 1/2D | GRIN1/GRIN2D | - | HEK 293 | |
| Acetylcholine Receptors | ||||
| Target | Gene | Disorder | Cell Type | |
| nAChR α4β2 | CHRNA4 / CHRNB2 | - | CHO | |
|
P2X Receptors |
||||
| Target | Gene | Disorder | Cell Type | |
| P2X1 | P2rx1 | - | CHO | |
| P2X2 | P2rx2 | - | CHO | |
| P2X2/3 | P2rx2/P2rx3 | - | CHO | |
| P2X3 | P2rx3 | - | CHO | |
| P2X4 | P2rx4 | - | HEK 293 | |
| P2X7 | P2rx7 | - | HEK 293 | |
| Glycine Receptors | ||||
| Target | Gene | Disorder | Cell Type | |
| GlyRα1 (h) | GLRA1 | - | CHO | |
| GlyRα2 (r) | GLRA2 | - | CHO | |
| GlyRα3 (h) | GLRA3 | Pain sensation | HEK 293 | |
| GlyRα3 (h) | GLRA3 | Pain sensation | CHO | |
| GlyRα3 (r) | GLRA3 | Pain sensation | CHO | |
| Serotonine Receptors | ||||
| Target | Gene | Disorder | Cell Type | |
| 5HT3A | 5HT3A | - | CHO | |
|
Acid sensing Receptors |
||||
| Target | Gene | Disorder | Cell Type | |
| ASIC1 isoform a | ACCN2 | - | CHO | |
| ASIC1 isoform b | ACCN2 | - | CHO | |
| ASIC1 isoform c | ACCN2 | - | CHO | |
| ASIC3 | ACCN3 | - | CHO | |
|
其他通道 |
||||
| Target | Gene | Disorder | Cell Type | |
| VDAC | VDAC1 | - | CHO | |
| PEPT1 | SLC15A1 | - | MDCK | |
| Stargazin | CACNG2 | Seizure disorders | HEK 293 | |
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