重组生物素化SARS-CoV-2 S1-RBD-SD1

特别提示：包括重组生物素化SARS-CoV-2 S1-RBD-SD1(Avi-His标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组生物素化SARS-CoV-2 S1-RBD-SD1(Avi-His标签)
英文名称：Biotinylated SARS-CoV-2 S Protein RBD-SD1 (C-Avi-6His)
产品货号：JN2093
产品规格：20μg|100μg

本制品由哺乳动物表达系统制备，目的基因编码表达SARS-CoV-2 Spike蛋白S1亚单位RBD域SD1片段(Arg319-Ser591)，C端含Avi-6*His标签，用作免疫原或标准品。

技术指标：
Accession#：QHD43416.1
分子量：33.2kDa
实测分子量：38-45kDa（还原条件下）
纯度：＞95%（还原性SDS-PAGE）
纯化方式：亲和色谱法
贮存液：PBS，pH7.4，0.2μm过滤
保存条件：-20℃。

生物活性：

Immobilized Human ACE-2-Fc(Cat#JN2061) at 2μg/ml (100μl/well) can bind Biotinylated SARS-CoV-2 S Protein RBD-SD1-Avi-His(Cat#JN2093).The ED₅₀ of Biotinylated SARS-CoV-2 S Protein RBD-SD1-Avi-His(Cat#JN2093) is 0.13μg/ml.

背景资料：
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation,apoptosis,cancer development and progression,and the innate immune response.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2,DPP4,CEACAM etc..The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.Most notable is severe acute respiratory syndrome (SARS).The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion.It is also a major immunogen and a target for entry inhibitors.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.

根据您的关注的重组生物素化SARS-CoV-2 S1-RBD-SD1(Avi-His标签)(＞95%)，Biotinylated SARS-CoV-2 S Protein RBD-SD1 (C-Avi-6His)，重组新型冠状病毒S-RBD-SD1，重组新型冠状病毒S1-RBD-SD1，重组新冠病毒S-RBD-SD1，重组Avi-His标签，重组Biotinylated SARS-CoV-2 S Protein RBD-SD1 (C-Avi-6His)，重组生物素化SARS-CoV-2 S1-RBD-SD1，重组新冠病毒S1-RBD-SD1，您可能还对以下产品有需求：



名称：重组小鼠OX40(TNFRSF4)(C端His标签)
货号：JN0487
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Val20-Pro211在C端含有His标签。

OX40/TNFRSF4质量控制：＞95%(还原性SDS-PAGE)

OX40/TNFRSF4制剂：冻干品

OX40/TNFRSF4保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

OX40/TNFRSF4复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于OX40/TNFRSF4：
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

关注重组生物素化SARS-CoV-2 S1-RBD-SD1(Avi-His标签)(＞95%)，Biotinylated SARS-CoV-2 S Protein RBD-SD1 (C-Avi-6His)，重组新型冠状病毒S-RBD-SD1，重组新型冠状病毒S1-RBD-SD1，重组新冠病毒S-RBD-SD1，重组Avi-His标签，重组Biotinylated SARS-CoV-2 S Protein RBD-SD1 (C-Avi-6His)，重组生物素化SARS-CoV-2 S1-RBD-SD1，重组新冠病毒S1-RBD-SD1的同时，为您推荐更多您可能感兴趣的产品：

 

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北京百奥莱博科技有限公司一家专注于生命科学研究领域的生物技术公司，坚持“质量至上，服务为本，全心全意助力生命科学”的理念，为广大用于提供稳定、可靠、专业的产品和服务支持，产品线包括分子生物学，细胞生物学，免疫检测，抗体，重组蛋白，血液制品等系列。“忙忙碌碌的平凡，铸就事业的不凡”。让我们携起手来，共同创造生命科学的蓬勃发展。