小鼠抗ERO1L单克隆抗体

特别提示：包括小鼠抗ERO1L单克隆抗体在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：小鼠抗ERO1L单克隆抗体
英文名称：ERO1L Antibody
产品货号：P11002
产品规格：50μL|100μL|150μL

宿主：小鼠
种属反应性：人、小鼠、大鼠
抗体类型：IgG2b
纯化方法：蛋白A纯化
浓度：1μg/μL
贮存液：PBS，50%甘油，含防腐剂
保存温度：-20℃


推荐应用及稀释比例：

应用	说明
WB	1:5000～50000
IHC	1:500～2000

蛋白别名：
ERO1 alpha
ERO1L
ERO1L alpha
ERO1 like (S.cerevisiae)
ERO1 like protein alpha
ERO1L

ERO1L相关说明：
ERO1L,also named as ERO1-alpha,is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds.It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange.It does not act as a direct oxidant of folding substrate,but relies on P4HB/PDI to transfer oxidizing equivalent.Associates with ERP44 but not with GRP54,demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins.Its reoxidation probably involves electron transfer to molecular oxygen via FAD.Glutathione may be required to regulate its activity in the endoplasmic reticulum.It may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell,thereby being a source of oxidative stress.It is required for the folding of immunoglobulin proteins.Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae,thereby playing a role in retrotranslocation of the toxin.

根据您的关注的小鼠抗ERO1L单克隆抗体，ERO1A抗体，ERO1α抗体，您可能还对以下产品有需求：


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关注小鼠抗ERO1L单克隆抗体，ERO1A抗体，ERO1α抗体的同时，为您推荐更多您可能感兴趣的产品：



名称：兔抗GAP43抗体
货号：YT715
规格：50μl
本品为来源于兔的抗GAP43的多克隆抗体。
宿主：兔
克隆性：多克隆抗体
用途：WB,FC, IHC,ICC, IF
交叉反应性：人，小鼠，大鼠
分子量：43KDa
推荐稀释比例：WB(1:1000),IF(1:200),IHC(1:200),ICC(1:200),FC(1:100-1:200)
 

About this Antibody
Name	GAP43 Rabbit Polyclonal Antibody
Category	Polyclonal antibody(pAb); Primary antibody
Isotype	IgG
Purification	Peptide affinity purified
About the Immunogen
Immunogen	This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to GAP43.
Gene ID	2596
SwissProt	P17677
Synonyms	B-50; PP46
Category	Neuroscience
Background	GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.

注意事项：
1. 如果本抗体用于Western blot (WB)、免疫荧光(IF)、免疫细胞化学(ICC)等实验，请注意回收使用过的稀释抗体。回收的抗体通常至少可以重复使用5-10次。稀释后的抗体，包括已经使用过的稀释抗体，请4℃保存。
2. 回收后重复使用的抗体，使用方法同新鲜稀释的抗体。如果在重复使用过程中发现抗体出现轻微混浊现象，可以10,000g离心1-3分钟，取上清用于后续检测。如果回收的抗体出现明显的絮状物或长霉长菌等情况，则可以考虑废弃该抗体。
3. 提供的Western一抗稀释液也可以用于免疫荧光(IF)、免疫组化(IHC)、免疫细胞化学(ICC)等适当用途。如果希望获得最佳的检测效果，请考虑使用上述检测专用的一抗稀释液。

储存条件：-20℃，有效期一年。

北京百奥莱博科技有限公司一家专注于生命科学研究领域的生物技术公司，坚持“质量至上，服务为本，全心全意助力生命科学”的理念，为广大用于提供稳定、可靠、专业的产品和服务支持，产品线包括分子生物学，细胞生物学，免疫检测，抗体，重组蛋白，血液制品等系列。“忙忙碌碌的平凡，铸就事业的不凡”。让我们携起手来，共同创造生命科学的蓬勃发展。