结肠癌肿瘤分子标志物检测试剂盒

结肠癌肿瘤分子标志物检测试剂盒

 货号: BR-1101C       规格: 96 Assay      价格: ￥3735.00

Colonic Neoplasms Molecular Marker (ERBB2,MAP2K6 and PTPN11) Detection Kit
 
Description: The kit provides a means of performing Colonic Neoplasms detection method based on kinase activity assays. Three targets of molecular marker (MAP2K6 and MAPK1) are involved in Colonic Neoplasms. This kit includes Streptavidin Coated Plates and specific Substrate-Peptides (biotinylated peptide substrates) for detection of the activity of MAP2K6 and MAPK1 which indicate the prognosis of Colonic Neoplasms. Molecular Markers in Colonic Neoplasms


 

Disease	Molecular Marker	Gene ID	Gene Disease Relation
Colonic Neoplasms	MAP2K6	5608	therapeutic
Colonic Neoplasms	MAPK1	5594	marker/mechanism

- Molecular markers for drug discovery and life science research (mechanism).


Peptide Core Sequence: 

Specific Substrate-Peptides for Colonic Neoplasms Molecular Marker

 

Molecular Marker	Substrate-Peptide	Residue	Active Site	Reaction_Type
MAP2K6	Peptides Mix	Tyr-182	182	Phosphorylation
MAPK1	Peptides Mix	Tyr-439	439	Phosphorylation

Label of Substrate-Peptides: Biotinylated.

Quality Control: The substrate peptide was selected using our Colonic Neoplasms Diagnosis Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.

Storage: 

Store at 4 °C, Avoid Freeze.


Background:

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17. MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis. Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
 
联系方式：
业务手机：18221844720   电话：021-34315602  邮箱：biopharmsoft@sina.com
 

公司简介：

拜珐（上海）信息技术有限公司是一家致力于生物医学、药学、高通量芯片技术、临床前药物开发、分子诊断、个性化治疗，生物检测试剂研发等科研领域的新兴高科技技术公司，总部位于美国亚利桑那州(Arizona –AZ) 。其产品BioPharm生物医药系统（BioPharm Information System）是公司自主研发的应用于药物筛选，生命科学研究，芯片数据分析，疾病机制研究的直观的科研系统。系统内不但有拥有自主知识产权的专业数据库，也有来源于文献资料的可靠的医药学专业信息；它不仅结合了NCBI，EMBL-EBI等已有生物医药数据库信息，也提供了简单易用的检索方式和丰富的检索类别。BPS是生命科学研究的必备工具之一。拥有本系统不但可以使研究者更快更轻松地获得所需的医药学关联信息，也可以极大地提高科学研究效率，把握研究领域的重点，节省宝贵的科研时间。BPS适用于靶向药物筛选，疾病和药物相关基因功能研究，生物芯片数据处理和芯片研发，实验参数查找，医学研究等。公司还致力于开发疾病诊断检测、蛋白芯片、基因芯片MicroArray、药物筛选产品和解决方案。

地址：上海市金山区荣昌路318号

邮编： 201518