慢性髓系白血病标志物检测试剂盒

慢性髓系白血病（BCR-ABL阳性）标志物检测试剂盒

Leukemia(Myelogenous, Chronic, BCR-ABL Positive) Molecular Marker (MAPK14) Detection Kit

Description: The kit provides a means of performing Leukemia (Myelogenous, Chronic, BCR-ABL Positive) detection method based on kinase activity assays. Three targets of molecular marker (MAPK14) are involved in Leukemia (Myelogenous, Chronic, BCR-ABL Positive). This kit includes Streptavidin Coated Plates and specific Substrate-Peptides (biotinylated peptide substrates) for detection of the activity of MAPK14 which indicate the prognosis of Leukemia (Myelogenous, Chronic, BCR-ABL Positive). 


Molecular Markers in Leukemia (Myelogenous, Chronic, BCR-ABL Positive)

 

Disease	Molecular Marker	Gene ID	Gene Disease Relation
Leukemia (Myelogenous, Chronic, BCR-ABL Positive)	MAPK14	1432	therapeutic
Leukemia (Myelogenous, Chronic, BCR-ABL Positive)	MAPK14	1432	therapeutic
Leukemia (Myelogenous, Chronic, BCR-ABL Positive)	MAPK14	1432	therapeutic

- Molecular markers for drug discovery and life science research (therapeutic).

Peptide Core Sequence: 

Specific Substrate-Peptides for Leukemia (Myelogenous, Chronic, BCR-ABL Positive) Molecular Marker

 

Molecular Marker	Substrate-Peptide	Residue	Reaction Type
MAPK14	Peptides Mix	Ser-543	Phosphorylation
MAPK14	Peptides Mix	Ser-387	Phosphorylation
MAPK14	Peptides Mix	Ser-726	Phosphorylation

Label of Substrate-Peptides:  Biotinylated

Quality Control: The substrate peptide was selected using our Leukemia (Myelogenous, Chronic, BCR-ABL Positive) Detection Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.

Storage: 
Store at 4 °C, Avoid Freeze.


Background:

Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
 
 
联系方式：
业务手机：18221844720   电话：021-34315602  邮箱：biopharmsoft@sina.com
 

公司简介：

拜珐（上海）信息技术有限公司是一家致力于生物医学、药学、高通量芯片技术、临床前药物开发、分子诊断、个性化治疗，生物检测试剂研发等科研领域的新兴高科技技术公司，总部位于美国亚利桑那州(Arizona –AZ) 。其产品BioPharm生物医药系统（BioPharm Information System）是公司自主研发的应用于药物筛选，生命科学研究，芯片数据分析，疾病机制研究的直观的科研系统。系统内不但有拥有自主知识产权的专业数据库，也有来源于文献资料的可靠的医药学专业信息；它不仅结合了NCBI，EMBL-EBI等已有生物医药数据库信息，也提供了简单易用的检索方式和丰富的检索类别。BPS是生命科学研究的必备工具之一。拥有本系统不但可以使研究者更快更轻松地获得所需的医药学关联信息，也可以极大地提高科学研究效率，把握研究领域的重点，节省宝贵的科研时间。BPS适用于靶向药物筛选，疾病和药物相关基因功能研究，生物芯片数据处理和芯片研发，实验参数查找，医学研究等。公司还致力于开发疾病诊断检测、蛋白芯片、基因芯片MicroArray、药物筛选产品和解决方案。

地址：上海市金山区荣昌路318号

邮编： 201518