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G蛋白活性抗体

英文名称：	Anti Active RhoA Mouse Monoclonal Antibody	总访问：	200
国产/进口：	进口	半年访问：	10
产地/品牌：	科博瑞	产品类别：	抗体
规格：	CR-M 26904	最后更新：	2024-5-24
货号：	CR-M 26904
CAS 号：
参考报价：	30μl/￥4800.00
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销售商：科博瑞（武汉）生物科技有限公司

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公司简介

Active RhoA GTP [CR-M26904]
[30 µL]

Catalog Number: CR-M26904

Gene Symbol: RHOA

Description: Anti Active RhoA Mouse Monoclonal Antibody

Background: Small GTPases are a super-family of cellular signaling regulators. RhoA belongs to the Rho sub-family of GTPases. Rho proteins play critical roles in many actin cytoskeleton- dependent processes including platelet aggregation, cell motility, contraction, and cytokinesis. It regulates the formation of stress fibers and focal adhesions in fibroblasts and Ca ²⁺sensitivity of smooth muscle contraction.

Immunogen: Recombinant full length protein of active RhoA

Applications: IP, IHC

Recommended Dilutions: 1 µg for 1~2 mg total cellular proteins for IP;
1:100 dilution for IHC

Concentration: 1 mg/ml

Host: mouse

Format: Liquid

Clonality: Monoclonal

Isotype: IgG2b

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS (without Mg ²⁺and Ca ²⁺), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Anti-active RhoA antibody recognizes active RhoA from vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Immunoprecipitation/Western Blot:

IP/WB analysis of active RhoA protein. Purified recombinant RhoA proteins wer
e loaded with GDP (lane 1) or GTPγS (lane 2). These proteins were immunoprecipitated
with anti active RhoA mouse monoclonal antibody (Cat. # CR-M26904). After SDS/PAGE, the
membrane filter was probed with anti RhoA mouse monoclonal antibody (Cat. # CR-M26007).

Publications:

1. Ethanol increases p190RhoGAP activity, leading to actin cytoskeleton rearrangements
J Neurochem. 2011 Dec;119(6):1306-16

2. The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1
Oncogene. 2012 Aug 30;31(35):3913-23

3. G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation
Carcinogenesis. 2010 Jul;31(7):1230-7

4. Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo
Development, Growth & Differentiation. Volume 55, Issue 4, pages 579–590, May 2013

5. Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis
Cell Death and Differentiation (2013) 20, 1031–1042

6. N-glycosylation induces collagen triple helix repeat containing 1 (CTHRC1) and drives oral cancer cell migration
J Biol Chem. 2013 Jul 12;288(28):20217-27

7. Cyclodextrin protects podocytes in diabetic kidney disease
Diabetes. 2013 Nov;62(11):3817-27

8. Amyloid beta1-42 (Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway
Journal of Neurochemistry Volume 127, Issue 2, pages 152–162, October 2013

9. Podocyte-specific GLUT4 deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy
Diabetes. 2014 Feb;63(2):701-14

10. Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells
Cell Death and Disease (2013) 4, e848

11. Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases
Biochimica et Biophysica Acta (BBA) - General Subjects Volume 1840, Issue 8, August 2014, Pages 2482–2490

12. Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours
J Cell Sci. 2014 Mar 15;127(Pt 6):1229-41

13. MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells
Cytokine Volume 69, Issue 1, September 2014, Pages 47–55

14. Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells
PLoS One. 2014 Oct 16;9(10):e110851

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