FGF-4细胞因子

▍Backgound

FGF-4 (fibroblast growth factor-4), also known as FGF-K or K-FGF (Kaposi’s sarcoma-associated FGF), is a 25 kDa secreted, heparin-binding member of the FGF family. The human FGF-4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF-4 (aa 71-206) shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF-4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. Its expression in the mouse trophoblast inner cell mass promotes expression of FGF R2, and is required for maintenance of the trophectoderm and primitive endoderm.

▍Source

Recombinant Human FGF-4 is expressed from Escherichia coli. It contains AA Ser 71 - Leu 206. Predicted molecular mass 19.6 kDa. This protein carries a polyhistidine tag at the N-terminus.

Recombinant Human FGF-4 is expressed from Escherichia coli

▍Endotoxin

Less than 1.0 EU per μg by the LAL method.

▍AA Sequence

SGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPG

MFIALSKNGKTKKGNRVSPTMKVTHFLPRL

▍Purity

Purity >95% as determined by SDS-PAGE.

▍Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.

▍Reconstitution

Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.

▍Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

▍SDS-PAGE

Human FGF-4, His Tag on SDS-PAGE under reducing (R) condition

Human FGF-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

厦门逸漠生物科技有限公司(Xiamen Immocell Biotechnology Co.,Ltd.)坐落于厦门国家留学创业园(翔安)产业园，是一家专注于细胞生物学领域新产品、新技术开发的高新技术企业。
公司拥有一支具有深厚造诣和丰富经验的高端技术人才，建设了高规格的研发实验室与生产车间，建立了规范的研发、生产、销售、客服管理体系。
公司与国内外多家医院、高等院校、科研院所、生物医药公司建立了良好的合作关系，赢得了良好的市场声誉和广泛的客户认可，将努力成为生命科学界可靠的合作伙伴和坚强的技术后盾。
企业文化我们的使命：
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我们的经营理念：
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