肝微粒体是体外研究一个化合物的代谢(酶抑制,清除率和代谢鉴定)以及药物-药物相互作用的主要工具。通常根据特定细胞色素酶的活性水平来选择微粒体。
齐氏生物提供的肝细胞微粒体,每批产品都经过严格的制备、检测,确保批次间稳定性,然后于冻存管包装,10 mg/管;-80℃保存,干冰运输。
用途:ADME及药代动力学检测试验
种属:人/大鼠/小鼠/兔/狗/猪/猴 /牛
规格:0.5ml 20mg/ml
运输:冻存管,干冰运输。
微粒体产品被SCI论文引用(部分):
1.Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites
Q Liu, Y Wang, CX Xiao, W Wu, X Liu - Food & function, 2015 - pubs.rsc.org
… 11–14 Moreover, chicoric acid has showed anti-inflammatory, anti-bacterial, anti-HIV
activities, hypoglycemic and hepatocyte protective properties …
Rat liver microsomes
were obtained from
CHI Scientific, Inc. (Massachusetts, USA)
文章链接:
https://doi.org/10.1039/C5FO00073D
2.
Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy
C Huang, J Zheng, D Ma, N Liu, C Zhu, J Li… - Journal of Materials …, 2018 - pubs.rsc.org
…
Rat liver microsomes were purchased from
CHI Scientific (Jiangsu China … under hypoxic conditions
(red curve); DDS in the presence of inactive rat liver microsomes and NADPH … 0 represent the
fluorescence intensity of TAMRA after and before rat liver microsome addition under …
文章链接:
https://doi.org/10.1039/C8TB01805G
附:产品介绍
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