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通用名称：游离甲状腺素（FT4）检测试剂盒（酶联免疫法）
英文名称：Thryoxine, Free (FT4) ELISA
【预期用途】
FT4 ELISA试剂盒用于定量测定人体内游离甲状腺素（fT4）。仅供科研使用，不用于体外诊断。
【包装规格】
96人份/盒
【背景知识】
血液中99%以上的甲状腺素（T4）与载体蛋白结合；甲状腺素结合球蛋白（TBG）。然而，只有甲状腺素的游离（未结合）部分才对生物作用负责。此外，在许多临床条件下，载体蛋白的浓度会发生改变，例如怀孕在正常甲状腺功能中，随着载体蛋白浓度的改变，总T4水平发生变化，游离T4浓度保持不变。因此，游离T4浓度的测量与临床状态的相关性比总T4水平更可靠。总T4水平的增加与妊娠、口服避孕药和雌激素治疗相关的水平导致总T4水平升高，而游离T4浓度基本保持不变。
【产品相关】
样本量：25 µl
灵敏度：0.4 ng/dl
储存温度：2-8 °C
参考文献：
1. Baker, S.B., “determination of protein bound Iodine”, Jornal Biological Chemistry 173, 175. (1948)
2. Chopra, I.J., Solomon, D.H., and Ho, R.S., “ A Radioimmunoassay of Thyroxine”, Jornal EndocrainoL 33, 865. (1971)
3. Young, D.S., Pestanger, L.C, and Giberman, U., “Effect ofDrugs on Clinical Laboratory Tests” , clinical chemistry 21, 3660.(1975)
4. Sterling, L., Diagnosis and Treatment of thyroid disease, Cleveland, CRC press P.19-51.(1975)
5. Halpem, E.P. and Bordens RW. “Microencapsulated antibodies in radioimmunoassay. Determination of free thyroxine”
6. Stjernholm, MR, Alsever, RN and Rudolph, MC. “Thyroid function test in diphenylhydantoin-treated patients”, clin. Chem.. vol. 21, 1388-1392. (1977)
7. Nelson, J.C. and Wilcox, RB. “ Analytical performance of free and total thyroxine assays”. Clin. Chem. Vol. 42, 146-154 (1996)
8. Midgeley john , EM. “ Direct and Indirect free thyroxine assay methods. Theory and practice” clin. Chem. Vol. 47, 1353-1363. (2001)
9. Bayer, MF and McDougall, IR. “ Radioimmunoassay of free thyroxine in serum. Comparison with clinical finding and results of conventional thyroid-function tests”clin. Chem. Vol. 26, 1186-1192. (1980)
10. Anthony, GW. Jackson, RA et. al. “Misleading results from immunoassays of serum free thyroxine in the presence of rheumatoid factor”, Clin. Chem vol. 43, 957-962. (1997)
11. Wosillait, WD. “ A theoretical analysis of the distributionof thyroxine among site on the thyroxine binding globulin, thyroid binding prealbumiun and serum albumin “. RES. Comm. Chem. Patho-pharmacology 16, 541-548. (1977).
