超氧化物歧化酶2重组兔单克隆抗体

别    名 IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN.   

研究领域 神经生物学  细胞凋亡  激酶和磷酸酶  线粒体   

抗体来源 Rabbit 

克隆类型 Monoclonal 

克 隆 号 3G5 

交叉反应 (predicted: Human, Mouse, Rat, ) 

产品应用 WB=1:1000-2000 IHC-P=1:50-200 IHC-F=1:50-200 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 22kDa 

细胞定位 细胞浆 线粒体 

性    状 Liquid 

浓    度 1mg/ml 

免 疫 原 KLH conjugated synthetic peptide derived from human SOD2:  

亚    型 IgG 

纯化方法 affinity purified by Protein A 

储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 

PubMed PubMed 

产品介绍 This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

 

Function:

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

 

Subunit:

Homotetramer.

 

Subcellular Location:

Mitochondrion matrix.

 

Post-translational modifications:

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.

Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.

 

DISEASE:

Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pa

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