转录因子SOX10重组兔单克隆抗体

别    名 DOM; MGC15649; SOX 10; SOX10_HUMAN; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Transcription factor SOX 10; Transcription factor SOX-10; WS4.   

研究领域 细胞生物  免疫学  神经生物学  干细胞  细胞凋亡  表观遗传学   

抗体来源 Rabbit 

克隆类型 Monoclonal 

克 隆 号 26D7 

交叉反应 (predicted: Human, Mouse, Rat, ) 

产品应用 WB=1:500-1000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 50kDa 

细胞定位 细胞核 细胞浆  

性    状 Liquid 

浓    度 1mg/ml 

免 疫 原 Recombinant human SOX10 protein (350-450aa):  

亚    型 IgG 

纯化方法 affinity purified by Protein A 

储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 

PubMed PubMed 

产品介绍 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

 

Function:

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia.

 

Subcellular Location:

Cytoplasm. Nucleus

 

Tissue Specificity:

Expressed in fetal brain and in adult brain, heart, small intestine and colon.

 

DISEASE:

Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E) [MIM:611584]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbanc

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