ADAM17重组兔单克隆抗体

中文名称 ADAM17重组兔单克隆抗体 

别    名 A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADA17_HUMAN.   

研究领域 肿瘤  免疫学  神经生物学  信号转导  转录调节因子   

抗体来源 Rabbit 

克隆类型 Monoclonal 

克 隆 号 9E7 

交叉反应 Human, Mouse,  (predicted: Rat, ) 

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:20-200 IHC-F=1:20-200 ICC=1:20-200 IF=1:20-200 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user. 

分 子 量 93kDa 

细胞定位 细胞膜  

性    状 Liquid 

浓    度 1mg/ml 

免 疫 原 Recombinant human ADAM17 protein:700-824/824 <Cytoplasmic> 

亚    型 IgG 

纯化方法 affinity purified by Protein A 

储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 

保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 

PubMed PubMed 

产品介绍 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].

 

Subunit:

Interacts with MAD2L1, MAPK14 and MUC1.

 

Subcellular Location:

Membrane.

 

Tissue Specificity:

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

 

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