重组人ACE2(mFc标签)

特别提示：包括重组人ACE2(mFc标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人ACE2(mFc标签)
英文名称：Recombinant Human Angiotensin-Converting Enzyme 2 (C-mFc)
产品货号：JN2063
产品规格：10μg|50μg

Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a mFc tag at the C-terminus.

Purity：Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin：＜0.1ng/μg (1 EU/μg) as determined by LAL test.

Storage：＜-20℃,stable for 6 months after receipt。Please minimize freeze-thaw cycles.

Formulation：
Supplied as a 0.2μm filtered solution of 20mM Tris-HCl,300mM NaCl,1mM ZnCl2,10% Glycerol,pH7.4.

Background：
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family,the ACE family includes somatic and germinal ACE.ACE-2 cleaves angiotensins I and II as a carboxypeptidase,ACE-2 converts angiotensin I to angiotensin 1-9,and angiotensin II to angiotensin 1-7.ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency.ACE-2 can be high expressed in testis,kidney and heart,in colon,small intestine and ovary at moderate levels.Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity.ACE-2 may play an important role in regulating the heart function.

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