重组SARS-CoV-2 S1-RBD(mFc tag)(＞95%)

特别提示：包括重组SARS-CoV-2 S1-RBD(mFc tag)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组SARS-CoV-2 S1-RBD(mFc tag)
英文名称：Recombinant SARS-CoV-2 Spike Protein (RBD, mFc Tag)
产品货号：Q15506
产品规格：100μg

纯度：
＞95% as determined by SDS-PAGE.
＞95% as determined by SEC-HPLC.

内毒素：＜1.0 EU per μg protein as determined by the LAL method.

生物活性：
Measured by its binding ability in a functional ELISA.
Immobilized human ACE2 protein (His tag) at 2μg/mL (100μL/well) can bind SARS-CoV-2 Spike Protein (RBD,mFc Tag)(CAT#:Q15506),the EC₅₀of SARS-CoV-2 Spike Protein (RBD,mFc Tag) is 15-50ng/mL.

蛋白构建：A DNA sequence encoding the SARS-CoV-2 Spike Protein (RBD) was expressed with the Fc region of mouse IgG1 at the C-terminus.

表达宿主：HEK293 Cells

预测N端：Arg

分子量：The recombinant SARS-CoV-2 Spike Protein (RBD,mFc Tag) consists of 457 amino acids and predicts a molecular mass of 51.5kDa.

缓冲液：
Lyophilized from sterile PBS,pH7.4.
Please contact us for any concerns or special requirements.
Normally 5% - 8% trehalose,mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.

运输方式：
In general,recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid.They are shipped out with blue ice unless customers require otherwise.

稳定性&储存条件：
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.

复溶：A hardcopy of COA with reconstitution instruction is sent along with the products.Please refer to it for detailed information.

背景资料：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2;DPP4,dipeptidyl peptidase-4;APN,aminopeptidase N;CEACAM,carcinoembryonic antigen-related cell adhesion molecule 1;Sia,sialic acid;O-ac Sia,O-acetylated sialic acid.The spike is essential for both host specificity and viral infectivity.The term "peplomer" is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.The main functions for the Spike protein are summarized as:Mediate receptor binding and membrane fusion;Defines the range of the hosts and specificity of the virus;Main component to bind with the neutralizing antibody;Key target for vaccine design;Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD),leading to a higher mortality rate.

根据您的关注的重组SARS-CoV-2 S1-RBD(mFc tag)(＞95%)，重组SARS-CoV-2 Spike Protein (RBD, mFc Tag)，重组SARS-CoV-2受体结合区，Recombinant SARS-CoV-2 Spike Protein (RBD, mFc Tag)，重组SARS-CoV-2 S1-RBD，重组mFc tag，您可能还对以下产品有需求：

 

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关注重组SARS-CoV-2 S1-RBD(mFc tag)(＞95%)，重组SARS-CoV-2 Spike Protein (RBD, mFc Tag)，重组SARS-CoV-2受体结合区，Recombinant SARS-CoV-2 Spike Protein (RBD, mFc Tag)，重组SARS-CoV-2 S1-RBD，重组mFc tag的同时，为您推荐更多您可能感兴趣的产品：



名称：重组人TMIGD2
货号：JN0209
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Leu23-Gly150在C端含有His标签。

TMIGD2质量控制：＞95%(还原性SDS-PAGE)。

TMIGD2制剂：冻干品

TMIGD2保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

TMIGD2复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于TMIGD2：
TMIGD2 is a single-pass type I membrane protein, which contains one Ig-like (immunoglobulin-like) domain. It is widely expressed in many tissues, such as epithelial, endothelial cells and lung. However, it isn’t detected in thyroid, cerebellum, thymus and cerebral cortex. TMIGD2 can form homophilic interactions that could regulate cell-cell interaction. It Interacts with CACNB2, DST, MIA and NCKIPSD. It is shown that TMIGD2 plays a role in cell-cell interaction, cell migration, and angiogenesis.

名称：重组人白介素IL-20(白细胞介素20)
货号：JN0356
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Leu25-Glu176表达纯化而来。

IL-20质量控制：＞95%(还原性SDS-PAGE)。

IL-20制剂：冻干品

IL-20保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-20复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-20：
Interleukin-20 (IL-20) is a member of the IL-10 family of regulatory cytokines that includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 exhibits approximately 28% amino acid identity with IL-10 and 76% amino acid identity with mouse IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 Rα and IL-20 Rβ. The second is composed of IL-22 R and IL-20 Rβ. Whereas the IL-22 R/IL-20 Rβ complex is shared with IL-24, the IL-20 Rα/IL-20 Rβ complex is shared with both IL-19 and IL-24. IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF-α and MCP-1. Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation, abnormal epidermal differentiation, and neonatal lethality. In humans, IL-20 and its receptors are up-regulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis. IL-20 may also have a role in hematopoiesis. It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice. IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.

北京百奥莱博科技有限公司一家专注于生命科学研究领域的生物技术公司，坚持“质量至上，服务为本，全心全意助力生命科学”的理念，为广大用于提供稳定、可靠、专业的产品和服务支持，产品线包括分子生物学，细胞生物学，免疫检测，抗体，重组蛋白，血液制品等系列。“忙忙碌碌的平凡，铸就事业的不凡”。让我们携起手来，共同创造生命科学的蓬勃发展。