重组SARS-CoV-2 S1蛋白(Fc tag)(＞85%)

特别提示：包括重组SARS-CoV-2 S1蛋白(Fc tag)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组SARS-CoV-2 S1蛋白(Fc tag)
英文名称：Recombinant SARS-CoV-2 Spike Protein S1 Subunit
产品货号：Q15509
产品规格：100μg

纯度：＞85% as determined by SDS-PAGE.

内毒素：＜1.0 EU per μg protein as determined by the LAL method.

蛋白构建：A DNA sequence encoding the SARS-CoV-2 spike protein S1 Subunit was expressed with the Fc region of human IgG1 at the C-terminus.

表达宿主：HEK293 Cells

预测N端：Val

分子量：The recombinant SARS-CoV-2 Spike Protein (S1 Subunit,Fc Tag) consists of 908 amino acids and predicts a molecular mass of 101.7kDa.

缓冲液：
Lyophilized from sterile PBS,pH7.4.
Please contact us for any concerns or special requirements.
Normally 5% - 8% trehalose,mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.

运输方式：
In general,recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid.They are shipped out with blue ice unless customers require otherwise.

稳定性&储存条件：
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.

复溶：
A hardcopy of COA with reconstitution instruction is sent along with the products.Please refer to it for detailed information.

背景资料：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2;DPP4,dipeptidyl peptidase-4;APN,aminopeptidase N;CEACAM,carcinoembryonic antigen-related cell adhesion molecule 1;Sia,sialic acid;O-ac Sia,O-acetylated sialic acid.The spike is essential for both host specificity and viral infectivity.The term "peplomer" is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.The main functions for the Spike protein are summarized as:Mediate receptor binding and membrane fusion;Defines the range of the hosts and specificity of the virus;Main component to bind with the neutralizing antibody;Key target for vaccine design;Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD),leading to a higher mortality rate.

根据您的关注的重组SARS-CoV-2 S1蛋白(Fc tag)(＞85%)，重组SARS-CoV-2 S1蛋白，重组SARS-CoV-2刺突蛋白S1亚单位，重组SARS-CoV-2 Spike Protein S1 Subunit，重组新型冠状病毒S1蛋白，重组Fc tag，Recombinant SARS-CoV-2 Spike Protein S1 Subunit，您可能还对以下产品有需求：



名称：重组人白介素IL-18(白细胞介素18)
货号：JN0383
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Tyr37-Asp193在C端含有His标签。

IL-18/IL-1F4质量控制：＞95%(还原性SDS-PAGE)。

IL-18/IL-1F4制剂：冻干品

IL-18/IL-1F4保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-18/IL-1F4复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-18/IL-1F4：
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

关注重组SARS-CoV-2 S1蛋白(Fc tag)(＞85%)，重组SARS-CoV-2 S1蛋白，重组SARS-CoV-2刺突蛋白S1亚单位，重组SARS-CoV-2 Spike Protein S1 Subunit，重组新型冠状病毒S1蛋白，重组Fc tag，Recombinant SARS-CoV-2 Spike Protein S1 Subunit的同时，为您推荐更多您可能感兴趣的产品：


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