重组HCoV-229E S蛋白(>85%)

特别提示：包括重组HCoV-229E S蛋白在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组HCoV-229E S蛋白
英文名称：Recombinant human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His Tag)
产品货号：Q20102
产品规格：100μg

纯度：> 85% as determined by SDS-PAGE.
内毒素：<1.0 EU per μg protein as determined by the LAL method.
表达宿主：Baculovirus-Insect Cells
种属：HCoV-229E
预测N端：Cys 16

蛋白构建：
A DNA sequence encoding the human coronavirus (HCoV-229E) spike protein (S1+S2 ECD) (APT69883.1) (Cys16-Trp1115) was expressed with a polyhistidine tag at the C-terminus.

分子量：
The recombinant human coronavirus (HCoV-229E) spike protein (S1+S2 ECD,His Tag) consists of 1111 amino acids and predicts a molecular mass of 122.1kDa.

缓冲液：Lyophilized from sterile 20mM PB,300mM NaCl,10% glycerol,pH7.5
Please contact us for any concerns or special requirements.
Normally 5% - 8% trehalose,mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.

运输方式：
In general,recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid.They are shipped out with blue ice unless customers require otherwise.

稳定性&储存条件：Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.

背景资料：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2;DPP4,dipeptidyl peptidase-4;APN,aminopeptidase N;CEACAM,carcinoembryonic antigen-related cell adhesion molecule 1;Sia,sialic acid;O-ac Sia,O-acetylated sialic acid.The spike is essential for both host specificity and viral infectivity.The term "peplomer" is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.It"s been reported that SARS-CoV-2 (COVID-19 coronavirus,2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.The main functions for the Spike protein are summarized as:Mediate receptor binding and membrane fusion;Defines the range of the hosts and specificity of the virus;Main component to bind with the neutralizing antibody;Key target for vaccine design;Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD),leading to a higher mortality rate.

根据您的关注的重组HCoV-229E S蛋白(>85%)，重组human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His Tag)，重组人冠状病毒229E S蛋白，重组HCoV-229E刺突蛋白，Recombinant human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His Tag)，您可能还对以下产品有需求：



名称：重组小鼠白介素IL-18(白细胞介素18)
货号：JN0408
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Asn36-Ser192在C端含有His标签。

IL-18/IL-1F4质量控制：＞95%(还原性SDS-PAGE)。

IL-18/IL-1F4制剂：冻干品

IL-18/IL-1F4保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-18/IL-1F4复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-18/IL-1F4：
Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in mouse is encoded by the IL18 gene, belongs to the IL-1 family. Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells

名称：重组人TNFSF10
货号：JN0469
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Val114-Gly281在C端含有His标签。

TNFSF10质量控制：＞95%(还原性SDS-PAGE)


TNFSF10制剂：冻干品

TNFSF10保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TNFSF10复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TNFSF10：
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.

关注重组HCoV-229E S蛋白(>85%)，重组human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His Tag)，重组人冠状病毒229E S蛋白，重组HCoV-229E刺突蛋白，Recombinant human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His Tag)的同时，为您推荐更多您可能感兴趣的产品：

 

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北京百奥莱博科技有限公司一家专注于生命科学研究领域的生物技术公司，坚持“质量至上，服务为本，全心全意助力生命科学”的理念，为广大用于提供稳定、可靠、专业的产品和服务支持，产品线包括分子生物学，细胞生物学，免疫检测，抗体，重组蛋白，血液制品等系列。“忙忙碌碌的平凡，铸就事业的不凡”。让我们携起手来，共同创造生命科学的蓬勃发展。