特别提示:包括重组SARS-CoV-2解旋酶(His标签)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:重组SARS-CoV-2解旋酶(His标签)
英文名称:Recombinant SARS-CoV-2 Helicase (C-6His tag)
产品货号:JN2072
产品规格:10μg|50μg
本制品由E.coli表达系统制备,目的基因编码表达SARS-CoV-2 Helicase(Ala1-Gln601),C端包含一个6*His标签。
Accession#:YP_009725308.1
蛋白别称:SARS-CoV-2 NSP13
贮存液:PBS,10% Glycerol,pH7.4,0.2μm过滤
分子量:70kDa
纯度:>90%(还原SDS-PAGE)
保存条件:-20℃,可稳定保存6个月,应避免反复冻融。
背景资料:
The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5"—3" polarity,using the energy of nucleotide hydrolysis.A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction,and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates.Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids.Initially,helicases were only thought to be molecular engines that unwind nucleic acids during replication,recombination,and DNA repair.Recent studies have shown that they are also involved in other biological processes,including displacement of proteins from nucleic acid,movement of Holliday junctions,chromatin remodeling,catalysis of nucleic acid conformational changes,several aspects of RNA metabolism,including transcription,mRNA splicing,mRNA export,translation,RNA stability and mitochondrial gene expression.Some human diseases,including Bloom’s syndrome,Werner’s syndrome,and Xeroderma Pigmentosum have been associated with defects in helicase function.
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重组SARS-CoV-2解旋酶(His标签)(>90%),重组新型冠状病毒Helicase,重组SARS-CoV-2 NSP13
贮存液:PBS,10% Glycerol,pH7.4,0.2μm过滤
分子量:70kDa
纯度:>90%(还原SDS-PAGE)
保存条件:-20℃,可稳定保存6个月,应避免反复冻融,Recombinant SARS-CoV-2 Helicase (C-6His tag),重组His标签,重组新型冠状病毒解螺旋酶,重组SARS-CoV-2 Helicase (C-6His tag),重组SARS-CoV-2解旋酶,重组SARS-CoV-2 NSP13,重组新冠病毒非结构蛋白13,重组SARS-CoV-2非结构蛋白13,您可能还对以下产品有需求:
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关注
重组SARS-CoV-2解旋酶(His标签)(>90%),重组新型冠状病毒Helicase,重组SARS-CoV-2 NSP13
贮存液:PBS,10% Glycerol,pH7.4,0.2μm过滤
分子量:70kDa
纯度:>90%(还原SDS-PAGE)
保存条件:-20℃,可稳定保存6个月,应避免反复冻融,Recombinant SARS-CoV-2 Helicase (C-6His tag),重组His标签,重组新型冠状病毒解螺旋酶,重组SARS-CoV-2 Helicase (C-6His tag),重组SARS-CoV-2解旋酶,重组SARS-CoV-2 NSP13,重组新冠病毒非结构蛋白13,重组SARS-CoV-2非结构蛋白13的同时,为您推荐更多您可能感兴趣的产品:
名称:重组人Long-R3-IGF1
货号:JN0211
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备,目的基因编码的Gly49-Ala118表达纯化而来。
IGF1(Long-R3-IGF1)质量控制:>95%(还原性SDS-PAGE)。
IGF1(Long-R3-IGF1)制剂:冻干品
IGF1(Long-R3-IGF1)保存:
冻干蛋白可在-20℃长期保存,室温也可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天。
复溶后建议分装冻存在-20℃,可保存3个月,应避免反复冻融。
IGF1(Long-R3-IGF1)复溶:
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存,避免反复冻融。
关于IGF1(Long-R3-IGF1):
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.
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