重组人颗粒酶B(>97%)

特别提示：包括重组人颗粒酶B在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人颗粒酶B
英文名称：Recombinant Human Granzyme B Protein (His Tag)
产品货号：Q10293
产品规格：10μg|20μg

纯度：>97% as determined by SDS-PAGE

内毒素：<1.0 EU per μg of the protein as determined by the LAL method

表达宿主：HEK293 Cells

种属：Human

预测N端：Gly 19

生物活性：
Measured by its ability to cleave a peptide substrate,tButyloxycaronylAlaAlaAspThioBenzylester (BocAADSBzl),in the presence of 5,5’Dithiobis (2nitrobenzoic acid) (DTNB).The specific activity is>1500pmol/min/μg.

蛋白构建：
A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.

分子量：
The recombinant human Granzyme B consists of 240 amino acids and has a calculated molecular mass of 27kDa.As a result of glycosylation,the apparent molecular mass of rhGranzyme B is approximately 36kDa in SDS-PAGE under reducing conditions.

缓冲液：
Lyophilized from sterile PBS,pH7.4
Please contact us for any concerns or special requirements.
Normally 5% - 8% trehalose,mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.

运输方式：
In general,recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid.They are shipped out with blue ice unless customers require otherwise.

稳定性&储存条件：
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.

复溶：
A hardcopy of COA with reconstitution instruction is sent along with the products.Please refer to it for detailed information.

背景资料：
Granzyme B,also known as GZMB,is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells.Granzyme B enters the target cells depending on another membrane-binding granule protein,perforin,results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways,and consequently induces rapid cell apoptosis.Over 3 substrates of GZMB have been identified including the key substrate caspase-3,ICAD and Bid.GZMB is suggested to protect the host by lysing cells bearing on their surface "nonself" antigens such as bacterial and viral infected-cells and tumor cells,and accordingly plays an essential role in immunosurveillance.

根据您的关注的重组人颗粒酶B(>97%)，重组人GZMB，重组Granzyme B Protein (His Tag)，重组人Granzyme B Protein (His Tag)，Recombinant Human Granzyme B Protein (His Tag)，人GZMB重组蛋白，您可能还对以下产品有需求：

 

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关注重组人颗粒酶B(>97%)，重组人GZMB，重组Granzyme B Protein (His Tag)，重组人Granzyme B Protein (His Tag)，Recombinant Human Granzyme B Protein (His Tag)，人GZMB重组蛋白的同时，为您推荐更多您可能感兴趣的产品：



名称：重组人化生长因子β2(TGF-β2)
货号：JN0267
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Ala303-Ser414表达纯化而来。

TGFB2质量控制：＞95%(还原性SDS-PAGE)。

TGFB2制剂：冻干品

TGFB2保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

TGFB2复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于TGFB2：
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).

北京百奥莱博科技有限公司一家专注于生命科学研究领域的生物技术公司，坚持“质量至上，服务为本，全心全意助力生命科学”的理念，为广大用于提供稳定、可靠、专业的产品和服务支持，产品线包括分子生物学，细胞生物学，免疫检测，抗体，重组蛋白，血液制品等系列。“忙忙碌碌的平凡，铸就事业的不凡”。让我们携起手来，共同创造生命科学的蓬勃发展。