PeproTech重组小鼠GPR15L

GPR15L is a newly identified ligand for GPR15, a member of the G protein‐coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15‐expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. While maintaining similar expression patterns and intramolecular disulfide cysteine bridges found in members of the CC chemokine family, GPR15L differs from classic CC and CXC chemokines, whose active sites are found on the N‐terminus, in that it relies on its C‐terminus for receptor interaction. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth. PeproTech’s E.coli‐derived Recombinant Murine GPR15L consists of 54 amino acid residues and has a calculated molecular weight of 6.3 kDa.

Source:E.coli

Synonyms:secreted protein C10orf99 homolog, RIKEN cDNA 2610528A11 gene, AW494830

AA Sequence:RRHPAKSLKL RRCCHLSPRS KLTTWKGNHT RPCRLCRNKL PVKSWVVPGA LPQI

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Product in testing.

Calculated Molecular Weight:6.3 kDa

Accession Number:A0A0B4J1N3

Gene ID:70045
Country Of Origin: USA

Not for human use

PeproTech Inc. 创立于1988年，始终致力于为生命科学研究开发重组蛋白及相关产品，如今已成为能提供多种高质量细胞因子和重组蛋白，相应的单克隆、多克隆和生物素标记抗体，以及ELISA试剂盒的世界领导者。PeproTech Inc.的产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。

为跟踪当今科研发展、满足日益增长的需求，PeproTech Inc.研制出无动物成分的重组蛋白(animal-free recombinant proteins)。有效地避免了动物源性污染引发潜在问题的可能性，从而可以应用于临床前研究和细胞治疗。此外，PeproTech Inc.最新还开发出无动物成分的培养基添加物试剂盒(animal-free Media Supplement Kits)。这些试剂盒经改良设计，其中的无血清组分对多种哺乳动物细胞的生长有更好的维持能力。

PeproTech Inc.的产品自2000年进入中国市场以来，以其优良的品质和合理的价格迅速得到国内各重点研究和实验机构的认可和青睐。鉴于中国经济发展的良好态势和中国生物医药研发投入的巨额增长，PeproTech Inc.于2009年10月在中国苏州设立代表机构，意为中国的广大用户提供更好的支持和服务，并助中国的科研和产业开发一臂之力。