DIO
品系名称：C57BL/6JNju DIO
品系类型：饮食诱导
品系编号：T002040、T002041
背景：C57BL/6JNju
DIO小鼠是指由高脂饮食诱导的肥胖小鼠模型，由于摄入过多脂肪酸，使体内脂肪合成增加并过度积累引起肥胖。大量文献证明机体的过度肥胖可导致脂肪及肝脏等组织的胰岛素受体敏感性下降，从而产生胰岛素抵抗等糖尿病症状[1-2]。
集萃药康在C57BL/6JNju小鼠5周龄时开始分别用60%高脂饲料（D12492）和40%高脂饲料（D09100301）喂养，进行诱导造模。此品系小鼠可表现出明显的体重增加，血糖升高、胰岛素水平下降及葡萄糖耐受受损等肥胖和糖尿病相关症状，可用于研究糖尿病、炎症、脂肪肝等代谢类疾病。60%DIO小鼠品系编号是T002040，40%DIO小鼠品系编号是T002041。
验证数据
参考文献
1. Oana Sandu1, Keying Song, et al. “Insulin Resistance and Type 2 Diabetes in High-Fat‒Fed Mice Are Linked to High Glycotoxin Intake.” Diabetes 2005 Aug; 54(8): 2314-2319.
2. NawelHamza, et al. “Treatment of high fat diet induced type 2 diabetes in C57BL/6J mice by two medicinal plants used in traditional treatment of diabetes in the east of Algeria.” Journal of Ethnopharmacology 27 January 2011, Pages 931-933.
