特别提示:包括兔抗人ERO1L抗体在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:兔抗人ERO1L抗体
英文名称:Rabbit Anti-ERO1L antibody
产品货号:A210020
产品规格:10μL|40μL|100μL
种属反应:小鼠、人
免疫原:人ERO1L(aa1-100)合成肽
宿主:兔
克隆:单克隆
抗体类型:IgG
贮存液:9% PBS;40%甘油,0.05% BSA,50%组织培养上清液,含防腐剂
保存条件:-20℃,避免反复冻融
推荐应用及稀释比例:
应用 |
说明 |
WB |
1:1000~10000 |
IHC-P |
1:100~250 |
ICC |
1:100~250 |
Flow Cyt |
1:10~100 |
IP |
1:10~100 |
ERO1L相关说明:
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds.Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange.Does not act as a direct oxidant of folding substrate,but relies on P4HB/PDI to transfer oxidizing equivalent.Associates with ERP44 but not with GRP54,demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins.Its reoxidation probably involves electron transfer to molecular oxygen via FAD.Acts independently of glutathione.May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell,thereby being a source of oxidative stress.Required for the folding of immunoglobulin proteins.Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae,thereby playing a role in retrotranslocation of the toxin.
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