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产品介绍
一个细胞背景，多种细胞应用；
拥有7500多基因敲除的细胞模型中可供学术界、生物技术和制药研究实验室信任和选择；
发表于Nature，Journal of Cell Science, Cell Reports等一系列同行评审文献支持。
产品特点
HAP1细胞系是单倍体基因型，每一个基因都只有一个拷贝，确保编辑后的等位基因不会被其他等位基因掩盖，所以HAP1细胞是基因编辑模型的一个很好的选择。
1）HAP1细胞的特征：
2）在被稀释成单细胞的条件下仍可维持生长
3）易于转染
4）快速的倍增时间
5）HAP1是来源于男性慢性粒细胞白血病（CML）细胞株KBM-7的人近单倍体细胞株。
应用领域
点击如下链接，选择应用领域，查询相应的HAP1细胞株。
https://horizondiscovery.com/applications/cell-line/cell-lines-by-research-area
规格参数
想知道是否感兴趣的基因已经有构建好的HAP1基因敲除细胞株，点击如下链接，输入基因名称，便可查询相关信息
https://horizondiscovery.com/products/gene-editing/cell-line-models/PIFs/Human-HAP1-Knockout-Cell-Lines
如需订购，请记录货号，联系我们。也可直接联系我们查询相关基因敲除的细胞株。
参考文献
使用HorizonDiscovery的HAP1突变细胞株，每年有大量文献发表。具体文献清单参考如下链接：
https://blog.horizondiscovery.com/hap1-peer-reviewed-scientific-articles
部分高分文献摘选
2019
（1）A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus Nature Communications
（2）Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response Nature Communications
（3）A Versatile Strategy to Reduce UGA-Selenocysteine Recoding Efficiency of the Ribosome Using CRISPR-Cas9-Viral-Like-Particles Targeting Selenocysteine-tRNA[Ser]Sec Gene Cells
（4）Bypassing pan-enterovirus host factor PLA2G16 Nature Communications
（5）iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture; Nature Comms
（6）PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression; Nature Comms
（7）Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes; PNAS
（8）A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus; Nature Comms
（9）Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells; Autophagy
2018
（1）Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy; Autophagy
（2）Accurate classification of BRCA1 variants with saturation genome editing; Nature
（3）The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication; Molecular Cell
（4）Validating the concept of mutational signatures with isogenic cell models; Nature Comms
（5）Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48; Nature Comms
更多详情请联系：
上海曼博生物医药科技有限公司
MineBio Life Sciences Ltd.
www.mine-bio.com
Tel: +(86) 21 51769110
Mobile: +(86) 13916844537（微信同号）
QQ：3117358847
Email: info@mine-bio.com
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