重组人CCL14蛋白惠诚生物优势供应

名称: CCL14
纯度:> 96 %
宿主:E. coli
种属:Human
生物活性:Testing in progress
蛋白构建:A DNA sequence encoding the amino acids (Gly 28-Asn 93) of human CCL14 (Q16627-1) was expressed, with a polyhistide tag at the N-terminus.
分子量:The recombinant human CCL14 (aa 28-93) consisting of 77 amino acids and has a calculated molecular mass of 9.3 kDa. It migrates as an approximately 12 kDa band in SDS-PAGE under reducing conditions.

CCL14是一种人类CC趋化因子，由于其在蛋白水解前8个nh2末端残基后，能够通过人类免疫缺陷病毒1型(HIV-1)共受体，CC趋化因子受体5 (CCR5)与之结合并发出信号，因此最近引起了人们的兴趣。
CCL14 Background Information：

CCL14 has an important biological role in other mammals by evolving under positive selection that has been lost in Ochotonidae (subgenera Pika and Lagotona). CC chemokine ligand 14, CCL14, is a human CC chemokine that is of recent interest because of its natural ability, upon proteolytic processing of the first eight NH2-terminal residues, to bind to and signal through the human immunodeficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5). Embryo implantation is a complex process involving blastocyst attachment to the endometrial epithelium and subsequent trophoblast invasion of the decidua. We have previously shown that the chemokines CX3CL1 and CCL14 are abundant in endometrial vasculature, epithelial, and decidual cells at this time, and that their receptors, CX3CR1 and CCR1, are present on invading human trophoblasts. CX3CL1 and CCL14 promote trophoblast migration.