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Cat. Number |
10-2147
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Chemical Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
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CAS Number |
231277-92-2
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Mol. Formula |
C29H26ClFN4O4S
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Mol. Weight |
581.06
|
Qty 1 |
10mg
|
Qty 2 |
50mg
|
Appearance |
Yellow solid
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Application Notes |
98% by TLC NMR (Conforms)
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Synonym |
GW-572016
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Solubility |
Soluble in DMSO (up to 200 mg/ml)
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Storage condition |
-20°C (des.)
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Stability |
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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References |
Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1 Clinically useful agent for treatment of breast cancer.2-3 Cell permeable References/Citations 1) Wood et al. (2004), A unique structure for epidermal growth fsctor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells; Cancer Res., 64 6652 拉帕替尼(碱) 英文名称Lapatinib (base) ,货号10-2147 上海惠诚提供10mg 50mg 拉帕替尼(碱) Lapatinib (base),美国focus原装进口,咨询电话021-60498804
拉帕替尼(碱) 英文名称Lapatinib (base) ,货号10-2147 上海惠诚提供10mg 50mg 拉帕替尼(碱) Lapatinib (base),美国focus原装进口,咨询电话17715331663
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