Securinine is an alkaloid found in Securinega leaves and roots that exhibits anticancer, antifungal, neuromodulatory, cognition enhancing, and neuroprotective activities. Securinine induces G1 phase cell cycle arrest, upregulates expression of p53 and Bax, and downregulates expression of Bcl-2, PI3K, mTOR, and p70s6k in breast cancer cells and promyelocytic leukemia cells. Securinine activates p38 MAPK, enhancing monocyte antibacterial activity in vitro as well. This compound also exhibits antimicrobial activity against Alternaria, Curvularia, and Helminthosporum. Additionally, securinine inhibits GABA-A receptors, decreases AChE activity, and suppresses amyloid-β (Aβ)-induced glial inflammatory responses in animal models of Alzheimer’s disease, improving cognitive deficits.
Securinan-11-one,CAS号:5610-40-2,分子式:C13H15NO2,分子量:217.26 上海惠诚生物现货提供。
上海惠诚生物科技有限公司 “惠质产品，挚诚服务”。Securinan-11-one 5610-40-2
上海惠诚生物特色产品：糖类标准品，脂肪酸标准品，花青素标准品，类胡萝卜素,人乳寡糖等食品分析标准品。
电话微信: 17715331663 QQ:2303607288
| Cat. Number |
S1609
|
| Chemical Name |
Securinan-11-one
|
| CAS Number |
5610-40-2
|
| Mol. Formula |
C13H15NO2
|
| Mol. Weight |
217.26
|
| Qty 1 |
10mg
|
| Appearance |
Yellow crystal
|
| Application Notes |
≥98%
|
| Storage condition |
Ambient
|
| References |
参考文献: Han S, Zhang G, Li M, et al. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway. Oncol Rep. 2014 May;31(5):2245-51. PMID: 24676995. Li M, Han S, Zhang G, et al. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Pharmazie. 2014 Mar;69(3):217-23. PMID: 24716413. Shipman M, Lubick K, Fouchard D, et al. Proteomic and systems biology analysis of monocytes exposed to securinine, a GABA(A) receptor antagonist and immune adjuvant. PLoS One. 2012;7(9):e41278. PMID: 23028424. Singh AK, Pandey MB, Singh S, et al. Antifungal Activity of Securinine against Some Plant Pathogenic Fungi. Mycobiology. 2008 Jun;36(2):99-101. PMID: 23990741. Lin X, Jun-Tian Z. Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35). Neurol Res. 2004 Oct;26(7):792-6. PMID: 15494124. Rana S, Gupta K, Gomez J, et al. Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells. FASEB. 2010 Jun;24(6):2126-2134. PMID: 20133503. |
Shanghai HuicH Biotech Co.，Ltd.
上海惠诚生物2010年至今专注于食品检测方面的标准品 ,优势品牌系列:
药物: TRC LGC USP LKT
植提标准品：Extrasynthese PhytoLab Chromadex CaroteNature
糖类: Elicityl TDB LUDGER Megazyme
脂类: Nu-Chek Larodan Avanti Matreya
其他: ABCAM TCI ERM WAKO Jackson Cayman laysan
手机微信：17715331663 QQ:2303607288
上海惠诚生物推荐产品:
