VISQUE InVivo Smart近红外荧光小动物活体实时成像系统
VISQUE InVivo Smart近红外荧光小动物活体实时成像系统是Vieworks公司生产的VISQUE系列的变革性创新产品,为了满足部分药学,纳米材料,纳米生物学,以及药物靶向输送和生物分布等研究方向的客户需求,寻求更多元化,便捷式的设备体验,Vieworks公司设计并研发了Smart系列的第一代产品——VISQUE Invivo Smart近红外荧光小动物活体实时成像系统。
VISQUE InVivo Smart近红外荧光小动物活体实时成像系统秉持了VISQUE系列产品一贯的设计风格,在保持了高灵敏度的荧光成像功能的基础上,配套了智能型的数据采集和分析软件系统,方便客户对更低浓度的荧光染料或者更弱的荧光信号实现快速,准确,高精度的成像,精巧的外观设计也大大便于客户的使用和移动,使得设备适应各种复杂拥挤的实验室环境。
VISQUE InVivo Smart近红外荧光小动物活体实时成像系统采用了科研级cmos相机,大大优化了高端的科研方向应用,在增强了量子效率,动态范围以及大大降低读数噪音的同时,保证了最小像素点可达20μm的高分辨率成像,实时的帧频采集速度也增加到了30fps。
VISQUE InVivo Smart近红外荧光小动物活体实时成像系统支持多达10种的动力学分析算法,用以进行实时成像后的药代动力学和生物分布等研究,便捷的ROI区域自动设置功能,方便用户快速设置感兴趣区,并分析感兴趣区内的荧光强度等信息进行半定量比较,设备数据可输出为TIFF,JPG,PNG,BMP等多种图片格式以及AVI等视频格式,ROI信息可直接输出为.CSV文件。系统还包含报告模式,可直接输出带采集图片时的设置信息的pdf报告。
为了体现用户友好型的设计理念,特别设计了能够便捷携带和运输的设备外观,整个设备不超过15kg,轻巧方便,占地面积更小,更适合个人实验室使用。
经典实验应用:
1. 脑血流实时成像:
2. 下肢血流实时成像:
3. 药物体内代谢研究:
市场上同类型产品成像效果对比:
部分引用文献:
一、2020年:
1. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Labeling and Tracking T Cells Via Dual-Modal Computed Tomography and Fluorescence Imaging,Biomacromolecules,2020;
2. Surface-Initiated Atom Transfer Polymerized Anionic Corona on Gold Nanoparticles for Anti-Cancer Therapy,Pharmaceutics,2020;
3. Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy,Journal of Controlled Release,2020;
4. Penta-fluorophenol: A Smiles rearrangement-inspired cysteine-selective fluorescent probe for imaging of human glioblastoma,Chemical Science,2020;
5. Heme Oxygenase 1‐Targeted Hybrid Nanoparticle for Chemo‐ and Immuno‐Combination Therapy in Acute Myelogenous Leukemia,Advanced Science,2020;
6. Detecting Cysteine in Bioimaging with a Near‐Infrared Probe Based on a Novel Fluorescence Quenching Mechanism,ChemBioChem,2020;
7. Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy,Journal of Medicinal Chemistry,2020;
8. In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a β-Galactosidase-Activatable Nanoprobe,Analytical Chemistry,2020;
9. Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer’s disease,Biomaterials,2020;
10. Precisely Traceable Drug Delivery of Azoreductase-Responsive Prodrug for Colon Targeting via Multimodal Imaging,Analytical Chemistry,2020;
11. Interrogation of Folic Acid-Functionalized Nanomedicines The Regulatory Roles of Plasma Proteins Reexamined,ACS Nano,2020;
12. Near-infrared probe based on novel fluorescence quenching mechanism for detection of cysteine in bioimaging,ChemBioChem,2020;
二、2019年:
1. A nanoscale photothermal agent based on a metal-organic coordination polymer as a drug-loading framework for effective combination therapy,Acta Biomaterialia,2019;
2. Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells,Journal of Industrial and Engineering Chemistry,2019;
3. Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance,Genome Research,2019;
4. Osteogenesis and angiogenesis are simultaneously enhanced in BMP2-/VEGF-transfected adipose stem cells through activation of the YAP/TAZ signaling pathway.,Biomaterials Science,2019;
5. Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-Mediated Photothermal Synergistic Immunotherapy,Nano Letters,2019;
6. CXCR4-Receptor Targeted Liposomes for the Treatment of Peritoneal Fibrosis,Molecular Pharmaceutics,2019;
7. pH-Switchable Coordinative Micelles for Enhancing Cellular Transfection of Biocompatible Polycations,ACS Applied Materials & Interfaces,2019;
8. Silicene: Wet-Chemical Exfoliation Synthesis and Biodegradable Tumor Nanomedicine,Advanced Materials,2019;
9. Self-Propelled Gemini-like LMWH-Scaffold Nanodrugs for Overall Tumor Microenvironment Manipulation via Macrophage Reprogramming and Vessel Normalization,Nano Letters,2019;
三、2018年:
1. Blood flow characteristics of diabetic patients with complications detected by optical measurements,BioMedical Engineering OnLine,2019;
2. 薄荷脑鼻用原位凝胶流变与凝胶特性研究,海军医学杂志,2019;
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