ViewnVivo小动物活体共聚焦成像系统
ViewnVivo小动物活体共聚焦成像系统采用了手持探头式成像方式，活体动物层面的最高分辨率可达到0.5微米级别，可在活体动物层面观察到组织或细胞的病理切片信息，细胞或亚细胞级别的染色信息，以及抗体表达、荧光染料、纳米粒子的分布情况等。
产品技术特点：
1. 最小0.5微米级别分辨率，可直接观察到活体的组织和细胞情况；2. 深度最高可达400μm，可进行不同层面扫描成像并合成3D结果；
3. 探头式成像，成像角度和位置更灵活，可观察更多切面；
4. 可进行实时动态采集，设置帧频采集速度并进行长时间采集；
5. 采用荧光成像的方式，可选用多种商业化的荧光探针，易标记；
6. 操作简单，无需复杂设置参数，无需专门人员负责；
应用领域：
1. 肝脏、肾脏、大脑、肿瘤等实质性脏器的成像及显微观察；
2. 口腔、呼吸道、胃肠道等腔道成像及显微观察；
3. 活体动物层面观察组织或细胞的病理切片信息；
4. 细胞的染色信息及抗体表达情况；
5. 荧光染料、纳米粒子的分布示踪；
6. 血管微循环信息；
经典案例应用：
案例一： 微血管成像与细胞示踪
案例二： 胃肠道成像
案例三：血管成像
相关文献：
一、2020：
1. Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers-Nature Biomedical Engineer-2020
2. Poly(ADP-ribose)polymerase1 A potential molecular marker to identify cancer during colposcopy procedures-Journal of Nuclear Medicine-2020
3. Fluorescence‑guided resection of tumors in mouse models of oral cancer-Scientific Reports-2020
二、2019：
4. Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging With Fluorescein-Frontiers in Oncology-2019
5. PARP1 as a biomarker for early detection and intraoperative tumor delineation in epithelial cancers – first-in-human results-bioRxiv-2019
6. Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E-Gastroenterology-2019
7. Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy-Stem Cell Research & Therapy-2019
8. Fluorescence Image histology pattern transformation using iamge style transfer-Frontiners in Oncology-2019
9. Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser -Nanomateria-2019
三、2018：:
10. Real-time-in Vivo Microscopic Imaging of Equine Endometrium Using Confocal Laser Endomicroscopy Preliminary Observations and Feasibility Study-Journal of Equine Veterinary Science-2018
11. Prospects for Theranostics in Neurosurgical Imaging：Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning-Advanced fluorescence imaging techniques in neurosurgery-2018
12. Probe-based three-dimensional confocal laser endomicroscopy of brain tumors technical note-Cancer Management and Research-2018
四、2017：:
13. The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction-Nature Reviews Gastroenterology & Hepatology-2017
14. Inhalation of methane preserves the epithelial barrier during ischemia and reperfusion in the rat small intestine-Surgery-2017
15. Improving utility of brain tumor confocal laser endomicroscopy objective value assessment and diagnostic frame detection with convolutional neural networks-SPIE Medical Imaging-2017
16. Evaluation of immunological markers of ovine vaginal irritation：Implications for preclinical assessment of non-vaccine HIV preventive agents_Journal of Reproductive Immunology-2017
17. Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis_Inflammopharmacology-2017
五、2016：
18. Reduced mucosal side-effects of acetylsalicylic acid after conjugation with tris-hydroxymethyl-aminomethane-Synthesis and biological evaluation of a new anti-inflammatory compound-European Journal of-2016
19. Handheld confocal laser endomicroscopic imaging utilizing imaging tumor‑specific fluorescent labeling to identify experimental glioma cells in vivo-SNI-2016
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