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销售商: 上海玉研科学仪器有限公司 | 查看该公司所有产品 >> |
PennCentury 气管内定量给药套装,适用于各种动物喷雾给药系统,肺部液体定量喷雾器,是一款能够在动物气管内将液体样品直接精确定量喷成气态,实现气态肺部给药的装置。通过精密的高压推送装置,将微量的液体定量传输至装置微喷头,微喷头集成在不锈钢细管中,纤细的细管可深入小鼠或大鼠的气管内,进而对动物肺部直接给药。
气管内定量给药装置的主要特色:
产品介绍:
· 快速、精确的直接肺部给药——气溶胶无浪费
· 纯机械 动力,无外部空气进入
· 不需加热、 推进剂、超声波或压缩空气等,对药物物影响
· 手持式设计的独特专利,使用非常方便
· 喷射头顶端圆滑的设计,保证安全、温和的插入气管内
· 可高温高压消毒灭菌,可重复使用
· 比其它雾化器和吸入设备提供更高浓度发药物体积或剂量
· 比传统滴注法给药提供更均匀的药物分布
Penn-Century MicroSprayer® Aerosolizer - Model IA-1C (liquid)
part number |
model |
description |
|
---|---|---|---|
MSA-250 |
MicroSprayer® Aerosolizer and FMJ-250 High-Pressure Syringe Assembly (Suitable for mouse and larger species) |
Penn-Century MicroSprayer® Syringe Assembly. Includes one standard MicroSprayer® Aerosolizer - Model IA-1C and one FMJ-250 High-Pressure Syringe (required for operation of the MicroSprayer® Model IA-1C). Standard sizes for mouse (1-1/4") or for rat (2") (Please specify). Both MicroSprayer® and syringe are autoclavable. Each device includes a set of five 25-µl stops and five 50-µl stops for precise dosing of smaller quantities. |
|
MSA-250-M |
For Mouse |
Standard size for mouse (1.25" after 120-degree bend) |
|
MSA-250-R |
For Rat |
Standard size for rat: (2" after 120-degree bend) |
|
MSA-250-C |
Custom Length |
Penn-Century MicroSprayer®/Syringe Assembly. Includes one custom length MicroSprayer® Aerosolizer - Model IA-1C and one FMJ-250 High-Pressure Syringe (required for operation of the Model IA-1C). MicroSprayer® Aerosolizer can be made to any length or configuration (e.g. short, long, with or without standard 120-degree bend), as specified by customer. Long lengths may be used with an endotracheal tube or bronchoscope. |
|
MSA-50 |
MicroSprayer® Aerosolizer and FMJ-50 High-Pressure Syringe Assembly (Suitable for mouse and larger species) |
Penn-Century MicroSprayer® Syringe Assembly. Includes one standard MicroSprayer® Aerosolizer - Model IA-1C and one FMJ-50 High-Pressure Syringe (new product for administration of up to five 10-µl doses) required for operation of the MicroSprayer® Model IA-1C. Standard sizes for mouse (1-1/4") or for rat (2") (Please specify). Both MicroSprayer® and syringe are autoclavable. |
|
MSA-50-M |
For Mouse |
Standard size for mouse (1.25" after 120-degree bend) |
|
MSA-50-R |
For Rat |
Standard size for rat: (2" after 120-degree bend) |
|
MSA-50-C |
Custom Length |
Penn-Century MicroSprayer®/Syringe Assembly. Includes one custom length MicroSprayer®Aerosolizer - Model IA-1C and one FMJ-50 High-Pressure Syringe (required for operation of the Model IA-1C). Each device includes a set of five 10-µl stops for precise dosing of smaller quantities. MicroSprayer® Aerosolizer can be made to any length or configuration (e.g. short, long, with or without standard 120-degree bend), as specified by customer. Long lengths may be used with an endotracheal tube or bronchoscope. |
|
Model IA-1C |
Additional MicroSprayer® Aerosolizers - Standard (Suitable for mice and all larger species.) |
With 23-gauge, stainless steel delivery tube, o.d. of 025" (.64 mm). NOTE: Must be operated with FMJ-250 High-Pressure Syringe. Standard sizes: 1-1/4" for mouse and 2" for rat after 120-degree bend. Fully autoclavable. |
|
IA-1C-M |
For Mouse |
Standard size for mouse (1.25" after 120-degree bend) |
|
IA-1C-R |
For Rat |
Standard size for rat: (2" after 120-degree bend) |
|
IA-1C-C |
Custom Length |
Custom sizes: any length or configuration (e.g. short, long, with or without standard 120-degree bend), as specified by customer. Long lengths may be used with an endotracheal tube or bronchoscope. Operated with FMJ-250 High-Pressure Syringe. |
|
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Penn-Century High-Pressure Syringes
part number |
model |
description |
|
---|---|---|---|
FMJ-250 |
Additional FMJ-250 High-Pressure Syringe |
Manually-operated, high-pressure syringe required for operating MicroSprayer® Aerosolizer - Model IA-1C. Operates at 3000 psi. Stainless steel construction with glass insert, 250 µl capacity. Replaceable plunger with Teflon® tip. Each device includes a set of five 25-µl stops and five 50-µl stops for precise dosing of smaller quantities. Fully autoclavable. |
|
PLU-250 |
Replacement Plunger for FMJ-250 |
Replacement plunger for FMJ-250 High Pressure Syringe - with anodized aluminum thumb button and Teflon® tip. |
|
FMJ-50 |
Additional FMJ-50 High-Pressure Syringe (for precise administration of up to five 10-µl doses) |
New low-dose model. Manually-operated, high-pressure syringe required for operating MicroSprayer® Aerosolizer - Model IA-1C. Operates at 3000 psi. Stainless steel construction with glass insert, 50 µl capacity. Replaceable plunger with Teflon® tip. Each device includes a set of five 10-µl stops for precise dosing of smaller quantities. Fully autoclavable. |
|
CBA |
Custom Bronchoscopic Adaptor |
NOTE: Longer, straight custom lengths of MicroSprayer® Aerosolizers - Model IA-1C can be ordered for insertion into the working channel of a bronchoscope for administration to a lobe of the lung. Depending on the configuration of the instrument port of the bronchoscope, an adaptor may be required to stabilize the FMJ-250 High Pressure Syringe and prevent bending of the MicroSprayer® during insertion and removal. The adapter must be custom fitted to your equipment in our shop. Please contact us for details. |
|
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Penn-Century MicroSprayers® (liquid) - Model IA-1B
part number |
model |
description |
|
---|---|---|---|
Model IA-1B |
MicroSprayer® Aerosolizer with 1 ml disposable polycarbonate syringe (Suitable for rat and all larger species) |
Made with stainless steel 19-gauge delivery tube that measures .048" (1.2 mm) at the very tip. Luer hub. Operates with 1-ml polycarbonate syringe (provided), or any commercially available 1-ml polycarbonate, or 0.5 ml glass, gas-tight syringe. Fully autoclavable. |
|
IA-1B-R |
For Rat |
Standard size for rat: (2" after 120-degree bend) |
|
IA-1B-GP |
For Guinea Pig |
Standard size for guinea pig (3" after 120-degree bend) |
|
IA-1B-C |
Custom Length |
Custom length MicroSprayer® Aerosolizers are available in any length or configuration (short, long, with or without standard 120-degree bend). May also be used via an endotracheal tube. Specify dimensions. |
|
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Penn-Century Dry Powder Insufflators™
part number |
model |
description |
|
---|---|---|---|
Model DP-4 |
Dry Powder Insufflator™ with disposable 3 ml air syringe |
Made of chemically resistant PEEK™ construction, silicone rubber valves, and hollow stainless steel delivery tube for precise administration of dry powders. Accepts all powder sizes. Air supply: 3 ml disposable air syringe (included). Standard sizes available for intratracheal administration to rat (2") or guinea pig (3"). |
|
DP-4-R |
For Rat |
Standard size for rat: (2" after 120-degree bend) |
|
DP-4-GP |
For Guinea Pig |
Standard size for guinea pig (3" after 120-degree bend) |
|
DP-4-C |
Custom length |
Custom size DP-4 with delivery tube: any length or configuration (straight or with standard 120-degree bend), as specified by customer. |
|
DP-EXT-R |
For Rat |
Extra delivery tube for DP-4 for Rat |
|
DP-EXT-GP |
For Guinea Pig |
Extra delivery tube for DP-4 for Guinea Pig |
|
DP-EXT-C |
Custom length |
Custom length tips for the Penn-Century Dry Powder Insufflator™ - Model DP-4 may be ordered in any length, straight or with a 120-degree bend, or with custom, flexible delivery tube options. Longer lengths may be inserted into an endotracheal tube or bronchoscope. (Specify dimensions) |
|
SC-X |
Sample Chamber Extension |
100 mg Sample Chamber Extension - attaches to Model DP-4 for administration of large doses |
|
DPM-APA |
Penn-Century Dry Powder Insufflator™/Air Pump Assembly for Mouse |
The only light, purely mechanical, manually operated method for intratracheal administration of dry powders to mouse. Includes (1) Penn-Century Dry Powder Insufflator™ for Mouse and (1) Penn-Century Air Pump with adjustable air volume setting (set for mouse at 200 µl). Insufflator made of chemically resistant PEEK™ construction with removable stainless steel delivery tube sized for intratracheal administration of dry powders to mouse. Operates with spring-loaded, Penn-Century Air Pump for easy, rapid administration of 200 µl pulses of air. |
|
Model DP-4M |
Additional DP-4M Dry Powder Insufflator™ for Mouse |
Dry Powder Insufflator™ with valve assembly for mouse. PEEK™ construction with silicone rubber valving. Can be used with any animal, including mouse, depending upon delivery tube dimensions. Comes with 23-gauge delivery tube (1.25" after the 120-degree bend). Operates with spring-loaded, Penn-Century Air Pump for easy, rapid administration of 200 µl pulses of air. |
|
DPM-EXT |
Extra delivery tube |
Extra delivery tube for DP-4M for Mouse |
|
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Penn-Century accessories for precise intratracheal aerosol administration
part number |
model |
description |
|
---|---|---|---|
AP-1 |
Air Pump |
Hand-held precision air pipette with spring-loaded thumb button for easy, fast administration of air pulses. Attaches to any size Penn-Century Dry Powder Insufflator™. Plastic construction with rubber square-ring seal. Outlet: male luer slip. Adjustable air volume setting: 0 - 5 ml. Required for use with DP-4M in mice. Recommended for use in rat, or in other applications requiring rapid dosing of multiple subjects with minimal hand motion. Specify animal to be used. |
|
LS-2 |
Small-Animal Laryngoscope |
Designed to clearly illuminate the trachea and epiglottis for intubation and insertion of a Penn-Century MicroSprayer® or Dry Powder Insufflator™. Now with a fiberoptic LED light source for clear, bright illumination. Each device comes with a custom-made small, tapered stainless steel blade for moving aside the animal's tongue. (Specify animal when ordering). New easy-grip handle with curved ergonomic shape fits securely in the palm of the hand. Coated with non-slip Santoprene™ rubber. Operates with one 3-volt lithium battery (included). Autoclavable. |
|
LS-2-M |
For Mouse |
With blade sized for use in Mouse |
|
LS-2-R |
For Rat |
With blade sized for use in Rat |
|
LS-2-GP |
For Guinea Pig |
With blade sized for use in Guinea Pig |
|
LS-2-C |
For larger species |
Custom blade for larger species. Please specify when ordering. |
|
MIP |
Mouse Intubation Platform |
For safe, rapid, easy intratracheal intubation of mice. Adjustable posts for stabilizing anesthestized animal. Unique swiveling neck support permits clearer visualization and access to trachea. Made of sterilizable Plexiglass®/Perspex® with stainless steel and Delrin® fittings. Can be attached to any standard lab clamp stand (not included.) NOTE: $50 discount is offered when Platform is purchased with any Penn-Century MicroSprayer® or Dry Powder Insufflator™. |
如需做大小鼠的气管插管,还可以选择大小鼠插管喉镜、气管插管平台、可调角度手术板、大小鼠气管插管工具包套装:
大小鼠喉镜
气管插管平台(多种款式和型号可选)
CG-02M型,适合做小鼠,外尺寸:20*15*20cm
CG-02R型,适合做大鼠,外尺寸:22*21*28cm
适用于大、小鼠的气管插管手术操作
CG-04M型,小鼠型
配合铁架台使用,多角度可调;
型号:CG-06M
多角度可调;
大小鼠通用,尺寸约:20*15*15cm
大小鼠气管插管工具包套装:
如需对动物进行自由活动状态下的全身染毒,可以选择气溶胶雾化暴露箱
大鼠、小鼠气溶胶染毒箱(全身暴露系统)可将药物、致敏原或其他混合物雾化为极细微的气溶悬浮颗粒送入置放动物的箱体中,动物按实验预定的时间曝露于其中,完成动物建模所需的致敏和激发过程;也可作为全身暴露系统对动物进行全身暴露;
(玉研仪器公司,可以根据客户需求订做特殊气体的染毒箱,如:硫化氢染毒箱、二氧化碳控制箱、二氧化硫染毒箱、一氧化碳染毒箱、氟化物染毒箱、氧气浓度控制箱等,欢迎来电咨询)
有多种尺寸和规格的暴露箱可供选择,还可根据需求进行订做:
全身暴露系统的主要特点:
Ø 同时针对多只动物建模,节省时间,一致性好。
Ø 根据有关文献,以OVA致敏为例,雾化方式建模比腹部注射方式所需时间短。
Ø 一体化的控制仪同时具有定时器功能、雾化参数设定及0~5LPM偏流供风系统。
Ø 偏流供风可在较长时间的致敏过程中为箱体内的动物提供新鲜空气,并保持箱体内的温度湿度不会过高。
Ø 提供雾化颗粒直径2.5~4μm和4~6μm两种雾化头供选择。
请根据暴露的实验动物的种类和数量,选择合适的暴露箱尺寸。
可搭配Aeroneb Lab雾化器,将药物雾化并推送到雾化箱内,持续雾化并维持暴露箱内一定的气溶胶浓度:
采用钯合金振动网格技术,中心孔板直径5mm,分布着1000个精密成形微孔,每秒振动128,000次,形成非常有利于深度肺部沉积的小液滴(气溶胶)
有两种雾化头可供选择:
标准:Volume Median Diameter(VMD)
雾化速率: >0.3mL/min
颗粒尺寸: VMD(体积中值直径)介于4.0μm-6.0μm
药物残余量: <0.1mL
小型:Volume Median Diameter(VMD)--推荐
雾化速率: >0.1mL/min
颗粒尺寸: VMD (体积中值直径)介于2.5μm and 4.0μm
药物残余量: <0.1mL
根据需要,您还可以选择美国BGI Collison气溶胶发生器
MRE型Collison气溶胶发生器是由英国波顿的Microbiological Research Establishment设计的平底型喷雾器,有1喷嘴,3喷嘴和6喷嘴多种型号可选,3喷嘴是最常用的型号。
金属部件都是由316不锈钢加工而来,O型圈是丁腈橡胶或硅橡胶,玻璃罐是冕牌玻璃制成。
BGI喷雾器顶部的”T”形杆既提供了空气进口,又可以连接了压力表。
24 Jet Collison喷雾器(24喷嘴的型号)是6喷嘴MRE改良型的扩大版。它有一个32盎司,干净覆膜的瓶子,以保持和3喷嘴、6喷射喷雾器相同的墙板间距尺寸,能够输出4倍左右于6喷嘴相同特性的气溶胶,但最大压力需要限制在30 PSIG。
下图是Collison气溶胶发生器配套动物染毒箱、压缩泵进行动物整体暴露染毒的图片:
(动物染毒箱,可以根据客户的需求订做合适的款式和尺寸,敬请来电咨询)
根据实验需求,您可能需要粉尘气溶胶发生器:
粉尘气溶胶发生器,可对粉尘颗粒进行雾化,产生稳定的粉尘气溶胶
小动物肺部定量给药套装的相关文献:
Wang J, Hong-Yan L, Hu-Shan W, et al. MicroRNA-485 modulates the TGF-β/Smads signaling pathway in chronic asthmatic mice by targeting Smurf2[J]. Cellular Physiology and Biochemistry, 2018, 51(2): 692-710.
Wu L, Rodríguez-Rodríguez C, Cun D, et al. Quantitative comparison of three widely-used pulmonary administration methods in vivo with radiolabeled inhalable nanoparticles[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 152: 108-115.
Wang P, Zhang L, Liao Y, et al. Effect of intratracheal instillation of ZnO nanoparticles on acute lung inflammation induced by lipopolysaccharides in mice[J]. Toxicological Sciences, 2020, 173(2): 373-386.
Peng J, Cai Z, Wang Q, et al. Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration[J]. Molecules, 2022, 27(11): 3610.
Tian X, Bera H, Guo X, et al. Pulmonary delivery of reactive oxygen species/glutathione-responsive paclitaxel dimeric nanoparticles improved therapeutic indices against metastatic lung cancer[J]. ACS Applied Materials & Interfaces, 2021, 13(48): 56858-56872.
Gu P, Wang D, Zhang J, et al. Protective function of interleukin‐22 in pulmonary fibrosis[J]. Clinical and Translational Medicine, 2021, 11(8): e509.
Weng C, Li G, Zhang D, et al. Nanoscale porphyrin metal-organic frameworks deliver siRNA for alleviating early pulmonary fibrosis in acute lung injury[J]. Frontiers in Bioengineering and Biotechnology, 2022, 10.
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